One of the most enduring successes of the last century is the extension of human life expectancy, due largely in part to advances in medicine, science and public health. This longevity, combined with a worldwide demographic shift — before 2020, for the first time in human history, people aged 65 and over will outnumber children under age 5, a phenomenon known as the “crossing” — presents challenges on a global scale. How do we extend human health, from disease prevention to cutting-edge treatments, to broad efforts to promote public health? What efforts in policy can prepare us for a changing society, where aging and living longer are quickly becoming new norms? How quickly do advances in technology, and growing stores of data about illnesses related to aging, such as Alzheimer’s Disease, bring us closer to understanding the human brain in its intricacies —in key functions such as memory, decision-making, personality and creativity? These questions and more will be jointly addressed by a cross-disciplinary team of leaders at USC.